Mimiviruses Interfere With IκBα Degradation

Many aspects of giant viruses biology still eludes scientists, with such as Acanthamoeba polyphaga mimivirus (APMV) and Tupanvirus (TPV) possessing large virions covered by fibrils are cultivated in laboratories using cells hosts. However, little is known about the infectivity these vertebrate cells. In present study, we investigated consequences incubation APMV mammalian These express Toll-like receptors (TLR) that capable recognizing lipopolysaccharides, favoring internalization antigen activation inflammatory system. By a lineage human lung adenocarcinoma (A549), found TPV virus particles interact internalized Furthermore, when treating fibriless variant APMV, M4 strain, there was no significant loss cell viability, reinforcing roles activation. addition, an upregulation TLR4 expression expected down regulation IκBα A549 or TPV-infected compared to non-infected Our results suggest mimiviruses able innate immune components TLR4, inducing their downstream signaling pathway, which ultimately active proinflammatory responses